Lepenica may refer to:
Bosnia and Herzegovina
- Lepenica (Fojnica), a river
- Lepenica (Rogatica), a village
- Lepenica, Tešanj, a village
Croatia
- Lepenica, Croatia, a village near Šibenik
Serbia
- Lepenica (Great Morava), a river
- Lepenica (region), a region
- Lepenica (Vladičin Han), a village
- Lepenica, Mačva, a village
